3h ago
Leads Biolabs wins IND clearance for PD-L1/4-1BB bispecific combo trial in metastatic colorectal cancer
Leads Biolabs has received approval for an investigational new drug (IND) application for its PD-L1/4-1BB bispecific antibody in metastatic colorectal cancer (mCRC). The therapy is intended for microsatellite stable (MSS) or mismatch repair proficient (pMMR) mCRC, a group that represents about 95% of mCRC cases and has shown limited response to conventional immune checkpoint inhibitors. Colorectal cancer sees about 1.926 million new cases and 904,000 deaths globally each year, ranking as the third most common cancer and the second leading cause of cancer-related death.
3h ago
3h ago
Apple shares slide 7.4% after forecast calls for 9%–11% revenue growth in fiscal Q4 2025
Apple lowered its fiscal fourth-quarter 2025 revenue growth outlook to 9%–11%, below analysts’ expectations of more than 12%. China sales came in at $18.8 billion versus an expected $19.6 billion, while services revenue of $30.7 billion missed a $31.4 billion forecast. Although total revenue of $109.4 billion beat estimates, the weaker guidance raised concerns about demand for new iPhone models and momentum in Greater China, sending the stock down 7.4% in its biggest one-day drop in nearly two years.
3h ago
4h ago
MV Electrosystems’ Rs 290 crore IPO draws 12.79x bids as Rs 1,800 crore Juniper Green issue stays under-subscribed
Two India IPOs are heading into their final day of bidding on Monday, with MV Electrosystems seeing strong demand while Juniper Green Energy remains under-subscribed. MV Electrosystems’ Rs 290 crore offer was nearly covered by institutional investors and drew heavy retail interest, whereas Juniper Green’s Rs 1,800 crore issue has yet to be fully subscribed. Analysts flagged customer concentration risk at Juniper Green, where the top two customers contribute 86.06% of FY26 revenue.
4h ago
4h ago
Shadowfax Technologies lifts FY27 revenue growth outlook to 38–40% after record Q1FY27 profit
Shadowfax Technologies posted Q1FY27 revenue of ₹1,358 crore, up 64.9% year on year and 9.8% quarter on quarter. Net profit rose 715.9% from a year earlier to a record ₹65 crore, while EBITDA margin expanded 370 basis points to 6.8%. On the back of the quarter, the logistics technology firm raised its FY27 revenue growth guidance to 38–40% from 27–30% and kept its margin targets unchanged. The company said momentum was supported by enterprise demand, more new customers, and growth in hyperlocal and ecommerce.
4h ago